AMDave
10-05-2017, 11:45 PM
Rosetta@home has contributed to a number of recent publications. Congratulations and thank you!
In Nature: building 20,000 new drug candidates. New de novo designed "mini-protein" binders were custom built to target either a deadly virus or a potent toxin and were shown to afford protection to mice. Read more (https://www.bakerlab.org/index.php/2017/09/28/new-article-nature-designing-testing-20000-new-protein-drug-candidates/).
https://boinc.bakerlab.org/rosetta/rah_img/NatureCover_01Sep2017.jpg (https://www.bakerlab.org/index.php/2017/09/28/new-article-nature-designing-testing-20000-new-protein-drug-candidates/)
Sensors for the potent opioid fentanyl. Using a fully-automated Rosetta design pipeline, high-affinity fentanyl sensors capable of detecting environmental fentanyl were produced. Read more (https://www.bakerlab.org/index.php/2017/09/25/sensors-potent-opioid-fentanyl/).
https://boinc.bakerlab.org/rosetta/rah_img/bick_binder-1.png (https://www.bakerlab.org/index.php/2017/09/25/sensors-potent-opioid-fentanyl/)
In Science: data-driven protein design. This work achieves the long-standing goal of a tight feedback cycle between computation and experiment and has the potential to transform computational protein design into a data-driven science. Rather than observing thousands of complex natural proteins to try to deduce their folding rules, over 15,000 new, simpler proteins were built – all designed using Rosetta. Through multiple design rounds, features that led to successful folding were learned and incorporated into the design pipeline. Read more (https://www.bakerlab.org/index.php/2017/08/27/data-driven-protein-design/).
https://boinc.bakerlab.org/rosetta/rah_img/grocklin-805x1024-1-150x150.png (https://www.bakerlab.org/index.php/2017/08/27/data-driven-protein-design/)
More... (https://boinc.bakerlab.org/rosetta/forum_thread.php?id=12244)
In Nature: building 20,000 new drug candidates. New de novo designed "mini-protein" binders were custom built to target either a deadly virus or a potent toxin and were shown to afford protection to mice. Read more (https://www.bakerlab.org/index.php/2017/09/28/new-article-nature-designing-testing-20000-new-protein-drug-candidates/).
https://boinc.bakerlab.org/rosetta/rah_img/NatureCover_01Sep2017.jpg (https://www.bakerlab.org/index.php/2017/09/28/new-article-nature-designing-testing-20000-new-protein-drug-candidates/)
Sensors for the potent opioid fentanyl. Using a fully-automated Rosetta design pipeline, high-affinity fentanyl sensors capable of detecting environmental fentanyl were produced. Read more (https://www.bakerlab.org/index.php/2017/09/25/sensors-potent-opioid-fentanyl/).
https://boinc.bakerlab.org/rosetta/rah_img/bick_binder-1.png (https://www.bakerlab.org/index.php/2017/09/25/sensors-potent-opioid-fentanyl/)
In Science: data-driven protein design. This work achieves the long-standing goal of a tight feedback cycle between computation and experiment and has the potential to transform computational protein design into a data-driven science. Rather than observing thousands of complex natural proteins to try to deduce their folding rules, over 15,000 new, simpler proteins were built – all designed using Rosetta. Through multiple design rounds, features that led to successful folding were learned and incorporated into the design pipeline. Read more (https://www.bakerlab.org/index.php/2017/08/27/data-driven-protein-design/).
https://boinc.bakerlab.org/rosetta/rah_img/grocklin-805x1024-1-150x150.png (https://www.bakerlab.org/index.php/2017/08/27/data-driven-protein-design/)
More... (https://boinc.bakerlab.org/rosetta/forum_thread.php?id=12244)