AMDave
01-14-2019, 10:00 PM
Another publication in Nature describing the first de novo designed proteins with anti-cancer activity
https://boinc.bakerlab.org/rosetta/rah_img/Neo2-15.png
A report was published in Nature last week describing the first de novo designed proteins with anti-cancer activity.
These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. We believe this is just the first of many computer-generated cancer drugs with enhanced specificity and potency.
R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!
Read the full article here: https://www.nature.com/articles/s41586-018-0830-7 (PDF (https://www.bakerlab.org/wp-content/uploads/2019/01/Silva2018_IL2-15.pdf))
More... (https://boinc.bakerlab.org/rosetta/forum_thread.php?id=12926)
https://boinc.bakerlab.org/rosetta/rah_img/Neo2-15.png
A report was published in Nature last week describing the first de novo designed proteins with anti-cancer activity.
These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. We believe this is just the first of many computer-generated cancer drugs with enhanced specificity and potency.
R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!
Read the full article here: https://www.nature.com/articles/s41586-018-0830-7 (PDF (https://www.bakerlab.org/wp-content/uploads/2019/01/Silva2018_IL2-15.pdf))
More... (https://boinc.bakerlab.org/rosetta/forum_thread.php?id=12926)