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Thread: New Project: SiDock@Home

  1. #1
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    New Project: SiDock@Home

    About SiDock@home project

    COVID.SI is a citizen science project to fight against SARS-CoV-2 by distributed computing.

    In our project, we are looking for ligands – small molecules that can successfully bind to protein targets and modulate a specific process that is crucial for the virus biochemistry. Together we have developed software that can be easily installed on your computer to help participants help find the cure for today’s invisible enemy. Based on molecular docking, the ideal ligand should be complementary in shape and properties to the binding site of the target biomolecule. However, the complementarity of small molecules is only one prerequisite for the use of a molecule as a drug.

    The search for the right molecule is best illustrated by finding a small needle in a huge haystack. It is a much more difficult problem because of the number of possible molecular structures. The amount of all possible molecular structures is also called the chemical universe – the size of this abstract space can be estimated to be 10 to the power of 80. There are many galaxies in this chemical universe, and one of the galaxies is a galaxy with potentially pharmacologically active molecules. The method for this purpose is called virtual screening. In principle, the larger the part of the chemical universe that we study, the higher the likelihood of finding a potential cure for the coronavirus.

    You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

    Project presentation "COVID.SI: Citizen science project to fight against SARS-CoV-2 by distributed computing" [En]
    Project presentation "COVID.SI: Проект гражданской науки для борьбы с SARS-CoV-2 при помощи распределенных вычислений" [Ru]

    For account creation please use Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

    Windows application requires theMicrosoft Visual C++ Redistributable for Visual Studio 2019 .

    Project can be found at https://fightcovid.boinc.ru/sidocktest/

  2. #2
    NeoGen's Avatar
    NeoGen is offline AMD Users Alchemist Moderator
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    Didn't see our team there yet so I created it

    https://fightcovid.boinc.ru/sidockte....php?teamid=45

    Join in vaughan and I'll transfer it to you.

    There's work flowing at least for Windows, I got a handful of it as soon as I joined.

  3. #3
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    And there's work for Linux too...
    To be more precise: there is work for 64-bit x86 CPUs, running a 64-bit version of either Windows, Linux or OSX.
    Last edited by Dirk Broer; 11-17-2020 at 12:53 PM.

  4. #4
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    I joined but my total focus for the next few days is PrimeGrid for the final challenge of the year.

  5. #5
    NeoGen's Avatar
    NeoGen is offline AMD Users Alchemist Moderator
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    I transferred the team foundership to you vaughan. Sentient_Life is leaving us all behind on the team stats

  6. #6
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    He'll keep.

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