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Thread: New Project: SiDock@Home

  1. #1
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    New Project: SiDock@Home

    About SiDock@home project

    COVID.SI is a citizen science project to fight against SARS-CoV-2 by distributed computing.

    In our project, we are looking for ligands – small molecules that can successfully bind to protein targets and modulate a specific process that is crucial for the virus biochemistry. Together we have developed software that can be easily installed on your computer to help participants help find the cure for today’s invisible enemy. Based on molecular docking, the ideal ligand should be complementary in shape and properties to the binding site of the target biomolecule. However, the complementarity of small molecules is only one prerequisite for the use of a molecule as a drug.

    The search for the right molecule is best illustrated by finding a small needle in a huge haystack. It is a much more difficult problem because of the number of possible molecular structures. The amount of all possible molecular structures is also called the chemical universe – the size of this abstract space can be estimated to be 10 to the power of 80. There are many galaxies in this chemical universe, and one of the galaxies is a galaxy with potentially pharmacologically active molecules. The method for this purpose is called virtual screening. In principle, the larger the part of the chemical universe that we study, the higher the likelihood of finding a potential cure for the coronavirus.

    You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

    Project presentation "COVID.SI: Citizen science project to fight against SARS-CoV-2 by distributed computing" [En]
    Project presentation "COVID.SI: Проект гражданской науки для борьбы с SARS-CoV-2 при помощи распределенных вычислений" [Ru]

    For account creation please use Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

    Windows application requires theMicrosoft Visual C++ Redistributable for Visual Studio 2019 .

    Project can be found at https://fightcovid.boinc.ru/sidocktest/


  2. #2
    NeoGen's Avatar
    NeoGen is offline AMD Users Alchemist Moderator
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    Didn't see our team there yet so I created it

    https://fightcovid.boinc.ru/sidockte....php?teamid=45

    Join in vaughan and I'll transfer it to you.

    There's work flowing at least for Windows, I got a handful of it as soon as I joined.

  3. #3
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    And there's work for Linux too...
    To be more precise: there is work for 64-bit x86 CPUs, running a 64-bit version of either Windows, Linux or OSX.
    Last edited by Dirk Broer; 11-17-2020 at 11:53 AM.


  4. #4
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    I joined but my total focus for the next few days is PrimeGrid for the final challenge of the year.

  5. #5
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    NeoGen is offline AMD Users Alchemist Moderator
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    I transferred the team foundership to you vaughan. Sentient_Life is leaving us all behind on the team stats

  6. #6
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    He'll keep.

  7. #7
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    We have a good performing international team on this project at the moment, see: AMD members by RAC
    Ocean Cloud is racing me to the Vitamin D badge at the moment, see AMD members by total score


  8. #8
    NeoGen's Avatar
    NeoGen is offline AMD Users Alchemist Moderator
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    I hit 100K on hit, I think I'm good for now here

    Oddly, I had my country set wrong. Just corrected it. Not sure how did that but I must have been in a hurry when I created the account.

  9. #9
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    The following is an email sent to you by an administrator of
    "Rechenkraft.net e.V.". If this message is spam, contains abusive or other
    comments you find offensive please contact the webmaster of the board at
    the following address:

    kontakt@rechenkraft.net

    Include this full email (particularly the headers).

    Message sent to you follows:
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~

    An alle Rechenkraft-Enthusiasten,
    ab Morgen 2 Uhr Ortszeit findet f?r eine Woche ein internationales
    Wettrechnen bei SiDock@home statt, bei dem wir Dich um Deine tatkr?ftige
    Unterst?tzung bitten wollen.
    Sidock@home Projektwebseite: https://www.sidock.si/sidock/

    Weitere Details inkl. Verlinkung auf die zugeh?rige Statistikseite und
    Diskussion finden sich hier:

    https://www.rechenkraft.net/forum/vi...188642#p188642

    SiDock@home hat f?r die drei top-platzierten Teams ein Sonder-B?tsch
    ausgelobt und das wollen wir erbeuten.
    Ich darf an dieser Steller zur weiteren Teilnahmemotivation vielleicht noch
    darauf hinweisen, dass Rechenkraft.net & das RNA World Team seit kurzem mit
    dem SiDock@home Forscherteam kooperiert und da wollen wir nat?rlich auch
    bie diesem Wettrechnen einen besonderen Beitrag leisten - zumal SiDock@home
    derzeit nach Wirkstoffen gegen das Coronavirus sucht und bereits an
    Labor?berpr?fungen einiger der von euch gefundenen Wirkstoffkandidten
    arbeitet.
    Gute Gr?nde also, f?r ein paar Tage mit unseren Rechnern voll reinzubuttern
    und hoffentlch s?ckeweise weitere Wirkstoffkandidaten aufzusp?ren!

    Beste Gr??e,
    Michael.


    Just briefly for our english speaking friends:
    Starting tomorrow at 2 am German time there is a challenge on SiDock@home.
    We would like to invite you to participate in our team for one week to try
    to acquire one of the three SiDock@home special badges as announced here:

    https://www.sidock.si/sidock/forum_thread.php?id=146

    Please join the Rechenkraft.net team and help find compounds to treat
    COVID19!

    Best regards,
    Michael.

    --
    Mit freundlichen Gr??en, die Administratoren von Rechenkraft.net

  10. #10
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    Quote Originally Posted by Dirk Broer View Post
    We have a good performing international team on this project at the moment, see: AMD members by RAC
    Ocean Cloud is racing me to the Vitamin D badge at the moment, see AMD members by total score
    Ocean Cloud seems to have stopped just before the credit level that gives the Vitamin D badge (249,615 of the needed 250,000)...

    The present challenge sees Vaughan, NormG, soheythere, Trond, chimanhvu and myself as participants, we could do with the help of Gamer007, SuicideCabbage, Ciceronian, Dan A. Lukens, Euphoriabuzz, cricket0597 and Ocean Cloud -to name but a few.
    Last edited by Dirk Broer; 09-17-2021 at 10:20 PM.


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