Heh, I have 4 and sometimes 5 projects running on my X2 +3800. Proteins at home is set to use 2 cores, Majestic-12 is running and D2OL is running too. I also have a "portable" version of D2OL that runs when I bring my USB memory stick home from work to reload - I leave it in to crunch over night then take it back to work to crunch on my work machine.

My poor overloaded system jumps back and forth from project to project, but I never, ever, run out of work.